Toward the modular synthesis of glycosaminoglycans: synthesis of hyaluronic acid disaccharide building blocks using a periodic acid oxidation

Autor:	Emma R. Palmacci, Peter H. Seeberger
Rok vydání:	2004
Předmět:	Glycosaminoglycan Chromium trioxide chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Hyaluronic acid Periodic acid Disaccharide Moiety Organic chemistry Glucuronic acid Biochemistry
Zdroj:	Tetrahedron. 60:7755-7766
ISSN:	0040-4020
DOI:	10.1016/j.tet.2004.06.037
Popis:	The synthesis of two differentially protected GluNAc-β(1→4)-GluA and GluA-β(1→3)-GluNAc disaccharide modules for the solid-phase assembly of hyaluronic acid are described. A periodic acid/chromium trioxide oxidation was the key transformation to facilitate access to the glucuronic acid moiety from glucose and should find wide application in the oxidation of primary alcohols.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be2d4a8049c96e458b51d2216e1303b9 https://doi.org/10.1016/j.tet.2004.06.037 Zobrazit plný text záznamu Full Text from ScienceDirect