Prognostic value of patient-reported outcomes (PROs) in advanced cancer

Autor: Anna Weinberg Chalmers, B. Haaland, Wallace Akerley, William A. Dunson, Shiven B. Patel, Jim Martineau, Laura Cannon, Tyler Haydell, Neal J. Meropol, Dominik Ose
Rok vydání: 2018
Předmět:
Zdroj: Journal of Clinical Oncology. 36:8-8
ISSN: 1527-7755
0732-183X
DOI: 10.1200/jco.2018.36.30_suppl.8
Popis: 8 Background: Performance status, which is prognostic of survival, is a physician’s interpretation of PROs. This retrospective study evaluated prognosis of PROs, independent of physician assessment, with overall survival (OS) and hospitalization-free survival (HFS). Methods: Patients (pts) at HCI were assessed using the NCI PROMIS-Ca bank from May 2016. Physical function (PF), fatigue, depression, anxiety, and pain scores were collected via iPad in pts with metastatic cancers. A single PRO score collected within 6 months of metastatic diagnosis for each pt was merged with outcome data using the Flatiron Health database. Associations between PROs, gender, cancer type, OS and HFS were assessed. Results: 287 complete sets of pt data were available. The PRO domains were interrelated with moderate-strong correlations (0.40-0.79). Cancer types differed by OS and HFS (p’s < 0.001). PF scores were worse for NSCLC than other cancers (p < 0.001). Individual PRO scores were worse for women than men, HFS was better for women and survival was not different. All individual PRO domains were strongly associated with HFS and OS. After correction for gender, cancer type, and individual PROs, only PF remained significant among individual PROs. Conclusions: PROs, especially PF, are prognostic of OS and HFS without physician interpretation. Gender difference may influence PROs. [Table: see text]
Databáze: OpenAIRE
Externí odkaz: