Circulating high density lipoprotein distinguishes alcoholic hepatitis from heavy drinkers and predicts 90-day outcome
| Autor: | Arun J. Sanyal, Hanchang He, Z. Gordon Jiang, Margery A. Connelly, Naga Chalasani, Eduardo Vilar-Gomez, Karan Mathur |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics Heavy drinker business.industry Endocrinology Diabetes and Metabolism Alcoholic hepatitis medicine.disease Gastroenterology chemistry.chemical_compound Liver disease High-density lipoprotein chemistry Disease severity Internal medicine Internal Medicine medicine lipids (amino acids peptides and proteins) Lipoprotein metabolism Cardiology and Cardiovascular Medicine Prospective cohort study business Lipoprotein |
| Zdroj: | Journal of Clinical Lipidology. 15:805-813 |
| ISSN: | 1933-2874 |
| DOI: | 10.1016/j.jacl.2021.10.002 |
| Popis: | Background Alcohol-associated liver disease (ALD) and alcoholic hepatitis (AH) significantly impact the liver, an organ central to the lipid and lipoprotein metabolism. Objective To define changes in the lipid and lipoprotein profiles in subjects with alcoholic hepatitis (AH) versus heavy drinkers with normal liver function and to determine the association of the AH-mediated lipoprotein phenotype with AH severity and outcomes. Methods AH cases (n=196) and a heavy drinker control group (n=169) were identified in a multicenter, prospective cohort. The relationships between lipid panels and lipoprotein profiles among AH and heavy drinkers were interrogated using three common measurements: the conventional lipid panel, extended lipid panel by NMR, and NMR-based direct lipoprotein profiling. Predictive values for AH severity and mortality were determined using Harrell's C-Index. Results Lipid and lipoprotein profiles were significantly different in AH compared to heavy drinkers. Among them, high density lipoprotein (HDL) particle concentration exhibited the most significant reduction in AH compared to heavy drinkers (5.3 ± 3.4 vs 22.3 ± 5.4 μmol/L, p Conclusion Lipid and lipoprotein profiles are profoundly altered in AH and can help in prognosticating disease severity and mortality. |
| Databáze: | OpenAIRE |
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