A novel ratiometric and reversible fluorescence probe with a large Stokes shift for Cu2+ based on a new clamp-on unit
| Autor: | Haipeng Wei, Han Wang, Xiao-Bing Zhang, Tao Guo, Hailong Tan, Yun-Hui Zhao, Lin Yuan, Yueyang Luo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Detection limit 010401 analytical chemistry Alkyne 02 engineering and technology 021001 nanoscience & nanotechnology Photochemistry 01 natural sciences Biochemistry Fluorescence 0104 chemical sciences Analytical Chemistry Ion symbols.namesake chemistry.chemical_compound chemistry Benzothiazole Stokes shift symbols Mass spectrum Environmental Chemistry Chelation 0210 nano-technology Spectroscopy |
| Zdroj: | Analytica Chimica Acta. 1065:134-141 |
| ISSN: | 0003-2670 |
| DOI: | 10.1016/j.aca.2019.03.029 |
| Popis: | A novel ratiometric and reversible chemosensor 4-((2-(Benzo[d]thiazol-2-yl)phenyl)ethynyl)-N,N-diethylaniline (BT-1) based on ortho-arylethynyl benzothiazole with large Stokes shift (Δλ≈190 nm) was designed and synthesized to recognize Cu2+. Copper ion induces a remarkable fluorescence enhancement and causes formation of a BT-1-Cu complex. The clamp-on coordination mode of BT-1 to Cu2+ was demonstrated using Job's plot, mass spectrum (MS) and DFT calculations. The calculations also indicate that Cu2+ was chelated to BT-1 through N and alkyne instead of S and alkyne. The probe could quantify Cu2+ with the detection limit of 3.2 × 10−9 M. The in vitro imaging results indicated that the probe BT-1 was membrane-permeable and could be applied into the recognition of Cu2+ ions in living cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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