Branched-chain Amino Acids and Relationship With Inflammation in Youth With Obesity: A Randomized Controlled Intervention Study
| Autor: | P. Babu Balagopal, Wagner Luiz do Prado, Ralph G Cosentino, Zarela Molle-Rios, Samantha Josephson, James R. Churilla, Jobayer Hossain |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Adiponectin business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Type 2 Diabetes Mellitus Context (language use) medicine.disease Biochemistry Obesity Amino acid Glutamine Endocrinology chemistry Internal medicine medicine Retinol binding business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 106:3129-3139 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgab538 |
| Popis: | Context Elevated concentrations of branched-chain amino acids (BCAA) are strong predictors of type 2 diabetes mellitus (T2DM). Their association with cardiovascular disease (CVD) remains uncertain, particularly in youth. Objective We investigated the role of BCAA and aromatic amino acids (AAA) in obesity, their relationships with novel biomarkers of CVD, and response to a physical activity-based lifestyle intervention (PAL-I) in a randomized controlled study in youth with normal weight (NW) and obesity (OB). Methods Age (14-18 years) and Tanner stage (≥IV) matched youth (OB, n = 15 and NW, n = 6) were studied; the 15 participants with OB underwent a 3-month randomized controlled PAL-I. Circulating amino acid profile, glucose, insulin, lipids, adiponectin, retinol binding protein-4, fibrinogen, high-sensitivity C-reactive protein, interleukin-6, and 25-hydroxy vitamin-D, along with body composition, were measured at baseline and after PAL-I. Independent t tests, analysis of covariance, and mixed-effect models were used for analysis of the data. Results Compared with NW, the concentration of various amino acids, including BCAA and AAA, were altered in OB (P 0.05) on BCAA and AAA. Glutamine, glycine, and aspartic acid decreased with PAL-I (all P Conclusion The novel finding of the BCAA–inflammation relationship, along with strong correlations with nontraditional biomarkers of CVD, may raise the prospect of BCAA as a biomarker of CVD and evoke a potential link between obesity, T2DM, and CVD. |
| Databáze: | OpenAIRE |
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