| Popis: |
Cardiomyopathy is one of the significant complications of diabetes mellitus. Hyperglycemia plays a central role in the pathogenesis of diabetic cardiomyopathy. The aqueous stem bark extract of Pterocarpus erinaceus was investigated for its phytochemical constituents, its effects on blood glucose level, lipid profile, antioxidants markers, and cardiac markers for heart tissue damage in alloxan induced diabetic wistar albino rats. Thirty five (35) rats were randomly divided into six groups. The animals in groups 2-6 were induced with a single dose of 150 mg/kg body weight of alloxan intraperitoneally. They were confirmed hyperglycemic after 72 hours of induction. Group 3 rats were treated with vitamin C as standard drug while group 4-6 were treated with P. erinaceus extract (100, 200 and 400 mg/kg body w. t) for 14 days. The results shows that P. erinaceus aqueous stem bark extract contains flavonoids as the most abundant constituent with concentration of (452.67±7.37 mg/100g). The aqueous stem bark extract given at dose of 100, 200 and 400 mg/kg decrease blood glucose concentration of rats by 44.26%, 47.16% and 74.41% respectively at 14th day of treatment. The rats treated with the plant extract shows significant decrease (p < 0.05) in triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels as well as significant increase (p |
