A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

Autor: David A. Jamison, S. Anand Narayanan, Nídia S. Trovão, Joseph W. Guarnieri, Michael J. Topper, Pedro M. Moraes-Vieira, Viktorija Zaksas, Keshav K. Singh, Eve Syrkin Wurtele, Afshin Beheshti
Rok vydání: 2022
Předmět:
Zdroj: European Journal of Human Genetics. 30:889-898
ISSN: 1476-5438
1018-4813
DOI: 10.1038/s41431-022-01108-8
Popis: COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus’ mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.
Databáze: OpenAIRE
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