Optimal prescribing of red cell transfusion in preterm infants
| Autor: | C A J Wardrop, H M Phillips, Barbara M. Holland, J. G. Jones |
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| Rok vydání: | 1987 |
| Předmět: | |
| Zdroj: | Pediatric Research. 22:219-219 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198708000-00035 |
| Popis: | Top of pageAbstract Today's tiny babies need frequent red cell transfusions (Tx). If inadequate red cells are Tx on each occasion, the donors and so infective hazards, are aultiplied. The objective of Tx is to achieve normal circulating red cell mass {RCM), but to avoid high blood viscosity. Calculations of the volume to Tx based only on the desired haematocrit (Hct) may underestimate the deficit in RCM because of variations in plasma volume. We have studied preterm infants before and 12 hours after Tx for blood loss and refractory anaemias: Group 1 - 13 Tx in babies aged birth - 10 days (mean = 4 days); Croup 2 = 21 Tx in babies aged 13-159 days (mean 36 days). We compared rises in Hct and RCM achieved with the various volumes of red cells transfused (mean ± 1SD) We have correlated pre-Tx Hct, volume of red cells* Tx and RCM achieved. Mathematical expressions have been derived for prediction of the volume of red cells* to Tx to achieve any desired RCM in the individual infant, eg. For our group 1, 16-29 ml red cells*/kg (mean 23) would achieve RCM of 50 ml/kg, approx normal for the term, infant. To avoid inordinate rises in Hct this may have to be given in more than one aliquot, monitoring the Hct at each stage. For group 2, 10-24 ml red cells/kg (mean 16) would achieve 35 ml/kg RCM. (*Pure red cells i.e. Hct = 1.0) 1Lancet April 86. i 862. Phillips et al. |
| Databáze: | OpenAIRE |
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