STUDIES ON THE IMMUNE RNA : SUBPOPULATIONS OF LYMPHOCYTES PARTICIPATING IN IMMUNE RESPONSE MEDIATED BY IMMUNE RNA
| Autor: | Tomoyuki Shibuya |
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| Rok vydání: | 1979 |
| Předmět: | |
| Zdroj: | The KITAKANTO Medical Journal. 29:71-77 |
| ISSN: | 1883-6135 0023-1908 |
| DOI: | 10.2974/kmj1951.29.71 |
| Popis: | Bone marrow cells (B-cells) and thymus cells (T-cells) collected from normal mice were separately incubated in vitro with immune (i) RNA. They were adoptively transferred to X-irradiated mice and their abilities to induce the increase in the number of specific antibody-carrying cells-and to induce the immunologic memory were investigated.The number of antibody-carrying cells increased in the spleens of recipient mice, which had been transferred with one of the following cell mixtures ; 1) the mixture of iRNA-treated T-cells (i-T) and iRNA-treated B-cells (i-B), 2) non-treated T-cells (n-T) and i-B, 3) i-B only, or 4) iRNA-treated spleen cells obtained from nude mice. By the contrast, it did not increase in the spleens of mice which had been transferred with the mixture of i-T and n-B, or n-T and n-B. By the antigenic stimulation at 4weeks after the cell transfer, the anamnestic (secondary) antibody-production response was observed in the recipient mice which had been transferred with the mixture of i-T and i-B, or of i-T and n-B, but was not in the recipients with the mixture of n-T and i-B, or of n-T and n-B. |
| Databáze: | OpenAIRE |
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