Synthesis and biological evaluation of new quinazolinone derivatives

Autor:	Firyal Weli Asker, Redha I. H. Al-Bayati, Hanaa Abd Al-Tamemi, Salma Abdul Rudha Abbas
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Antioxidant Stereochemistry Chemistry medicine.medical_treatment Antimicrobial Broad spectrum chemistry.chemical_compound Enzyme Proton NMR medicine Organic chemistry Quinazolinone Biological evaluation
Zdroj:	European Journal of Chemistry. 5:628-634
ISSN:	2153-2257 2153-2249
DOI:	10.5155/eurjchem.5.4.628-634.1120
Popis:	New N -substituted-2-methyl quinazolin-4(3 H )-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1 H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::be09a7c851aacd1a1628b77d8fd5a5b8 https://doi.org/10.5155/eurjchem.5.4.628-634.1120 Zobrazit plný text záznamu