ZnBr2-SiO2 catalyzed green synthesis of tetrazoles: Molecular docking and antioxidant activity studies
| Autor: | Subba Rao Devineni, Jyothi Kumar Malaka Venkateshwarulu, Chenna Krishna Reddy Reddivari, Naga Raju Chamarthi, Appa Rao Chippada, Rajendra Wudayagiri, Vijaya Bhaskar Baki, Rami Reddy Yallala Venkata |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | European Journal of Chemistry. 8:66-75 |
| ISSN: | 2153-2257 2153-2249 |
| DOI: | 10.5155/eurjchem.8.1.66-75.1515 |
| Popis: | A series of 5-substituted and 1,5-disubstituted tetrazoles were synthesized in high yields from various biologically active substituted nitriles with sodium azide under heterogeneous catalysed (ZnBr 2 -SiO 2 ) [2+3] cycloaddition conditions. This reaction gave an excellent yield in the presence of catalytic amount of 0.2 g of ZnBr 2 -SiO 2 , glycerol solvent system under microwave irradiation conditions. All the prepared compounds were characterized by elemental analysis 1 H NMR, 13 C NMR, FT-IR, and mass spectral data. The newly synthesized compounds were investigated for their respective molecular target using molecular docking studies. The results reveal that compounds 5a, 5c, 5e and 3e have conferred with multi target property. The compounds 5a, 5c and 5e have shown the highest binding affinities of -10.1, -9.7 and -10.6 with reverse transcriptase, -8.5, -8.2 and -8.9 with Aurora B, respectively. The compounds 5a, 5e and 3e have shown -8.9, -8.5 and 8.4 with Aromatase, respectively. In addition, the antioxidant activity data reveals that all the compounds showed good antioxidant activity, particularly the compounds 3d, 5d, and 5e exhibited promising radical scavenging activity. |
| Databáze: | OpenAIRE |
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