17 Insulin secretion induced by immune responses
| Autor: | J C Basabe, E De Alvarez, Juan Antonio García, M Arata, O Pivetta, L Bruno |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
medicine.medical_specialty
Insulin medicine.medical_treatment Biology Major histocompatibility complex medicine.anatomical_structure Endocrinology Immune system Allogeneic Lymphocyte Internal medicine Pediatrics Perinatology and Child Health medicine biology.protein Syngenic Secretion Pancreas Incubation |
| Zdroj: | Pediatric Research. 15:178-178 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | The effect of SRBC and of allogeneic lymphocytes (AL) injection, on insulin(I) secretion in incubated pancreas slices of BALB/c mice;is studied.SRBC injected in BALB/c,induces an incease in the insulin secretion stimulated by 11mM glucose (G).Pancreas obtained from BALB/c(H2d) injected with lymphocytes of C57B1/6J (H2b), produces a higher insulin secretion than that injected with syngenic lymphocytes. There is no difference in the I secreted by BALB/c pancreas, when the mice were injected with BALB/c (H2d) or C57B1/Ks(H2d) lymphocytes. When 1/10 from BALB/c mice injected with C57B1/6J lymphocytes,is used as incubation medium, I secretion, is higher than when buffer or serum of BALB/c injected with syngenic lymphocytes is utilized. The results suggest that: a)SRBC and AL, increase the I secretion induced by G.,b)This effect seems to be related to the major histocompatibility complex. c) even a direct action of AL. can not be rouled out, AL. injection could produce the release into serum of some substance(s) that stimulate insulin secretion. |
| Databáze: | OpenAIRE |
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