Synthesis and Antimalarial Activity of Dihydroperoxides and Tetraoxanes Conjugated with Bis(benzyl)acetone Derivatives
| Autor: | Lucas Lopardi Franco, Pedro Paulo Ribeiro Vieira, Mauro V. de Almeida, Luiz Francisco Rocha e Silva, Adrian Martin Pohlit, Marcelo Siqueira Valle |
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| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
biology medicine.drug_class Stereochemistry Chemistry Organic Chemistry Plasmodium falciparum Conjugated system biology.organism_classification Biochemistry In vitro Benzyl acetone parasitic diseases Drug Discovery Antiprotozoal medicine Molecular Medicine Structure–activity relationship Inhibitory concentration 50 Tetraoxanes |
| Zdroj: | Chemical Biology & Drug Design. 79:790-797 |
| ISSN: | 1747-0277 |
| DOI: | 10.1111/j.1747-0285.2012.01345.x |
| Popis: | Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC50 ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum. |
| Databáze: | OpenAIRE |
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