Hepatitis C—diagnosis and monitoring
| Autor: | Patricia M. Laurenson, Linda J. Wuestehube, Mickey S. Urdea, Judith C. Wilber |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
biology
medicine.diagnostic_test business.industry Hepatitis C virus Hepacivirus Biochemistry (medical) Clinical Biochemistry virus diseases Hepatitis C medicine.disease medicine.disease_cause biology.organism_classification Virology law.invention Serology law Therapeutic drug monitoring Immunology BDNA test Medicine Viral disease business Polymerase chain reaction |
| Zdroj: | Clinical Chemistry. 43:1507-1511 |
| ISSN: | 1530-8561 0009-9147 |
| Popis: | Cloning of the hepatitis C virus (HCV) genome was a tremendous advance in the development of tests for diagnosis and monitoring of HCV-infected patients. Serological tests, including enzyme-linked immunoassays and RIBATM strip immunoblot assays, are primarily used to screen blood donations and to diagnose and confirm HCV infection. Tests for HCV RNA, including polymerase chain reaction (PCR)-based assays and the branched-DNA (bDNA) assay, are used for therapeutic monitoring and prognostics. Here, we present the development and future potential of these diagnostic tests. We also provide examples of how these tests are used to follow the progression of disease, select and adjust treatment protocols, and evaluate the efficacy of therapeutic regimens. |
| Databáze: | OpenAIRE |
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