Novel nucleosides via intramolecular functionalization of 2,2′-anhydrouridine derivatives

Autor:	Michael E. Jung, S. S. O'rourke, David P. Sebesta, Rogelio L. Martinez, Danny P. C. McGee, Wolfgang Pieken
Rok vydání:	1996
Předmět:	Reaction conditions Chemistry Intramolecular force Organic Chemistry Drug Discovery Nucleophilic substitution Surface modification Stereoselectivity Ribonucleoside Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron Letters. 37:1995-1998
ISSN:	0040-4039
DOI:	10.1016/0040-4039(96)00227-4
Popis:	The generation of novel ribonucleoside analogues derived from 2,2′-anhydrouridines by a 3′-hydroxyl directed intramolecular nucleophilic substitution of the 2′-position is described. The methodology allows for the efficient, regio- and stereoselective elaboration of the 2′-position, often under exceptionally mild reaction conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bddfcc1a9c589edb25ae2b768af8e713 https://doi.org/10.1016/0040-4039(96)00227-4 Zobrazit plný text záznamu Full Text from ScienceDirect