Dietary interventions for fetal growth restriction - therapeutic potential of dietary nitrate supplementation in pregnancy
| Autor: | Laura Ormesher, Colin P. Sibley, Edward D. Johnstone, Susan L. Greenwood, Mark Wareing, Teresa Tropea, Elizabeth Cottrell, Jenny Myers |
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| Rok vydání: | 2017 |
| Předmět: |
Fetus
Pregnancy 030219 obstetrics & reproductive medicine biology Physiology Maternal Nutritional Physiological Phenomena Endogeny 030204 cardiovascular system & hematology medicine.disease Nitric oxide Bioavailability Nitric oxide synthase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure chemistry Biochemistry Placenta medicine biology.protein |
| Zdroj: | The Journal of Physiology. 595:5095-5102 |
| ISSN: | 0022-3751 |
| Popis: | Fetal growth restriction (FGR) affects around 5% of pregnancies and is associated with significant short- and long-term adverse outcomes. A number of factors can increase the risk of FGR, one of which is poor maternal diet. In terms of pathology, both clinically and in many experimental models of FGR, impaired uteroplacental vascular function is implicated, leading to a reduction in the delivery of oxygen and nutrients to the developing fetus. Whilst mechanisms underpinning impaired uteroplacental vascular function are not fully understood, interventions aimed at enhancing nitric oxide (NO) bioavailability remain a key area of interest in obstetric research. In addition to endogenous NO production from the amino acid l-arginine, via nitric oxide synthase (NOS) enzymes, research in recent years has established that significant NO can be derived from dietary nitrate, via the 'alternative NO pathway'. Dietary nitrate, abundant in green leafy vegetables and beetroot, can increase NO bioactivity, conferring beneficial effects on cardiovascular function and blood flow. Given the beneficial effects of dietary nitrate supplementation to date in non-pregnant humans and animals, current investigations aim to assess the therapeutic potential of this approach in pregnancy to enhance NO bioactivity, improve uteroplacental vascular function and increase fetal growth. |
| Databáze: | OpenAIRE |
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