Peroxidation Products and Antioxidant Enzyme Activities in Multinodular Goiter and Papillary Thyroid Cancer Patients
| Autor: | Bahadır Çetin, Can Atalay, Melih Akinci, Zeki Ari, Funda Kosova, Ahmet Seki, Osman Uyar |
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| Rok vydání: | 2014 |
| Předmět: |
endocrine system
medicine.medical_specialty Goiter endocrine system diseases business.industry medicine.medical_treatment Thyroid disease Thyroid Thyroidectomy medicine.disease Papillary thyroid cancer Lipid peroxidation chemistry.chemical_compound medicine.anatomical_structure Endocrinology Advanced oxidation protein products chemistry Internal medicine medicine business Thyroid cancer |
| Zdroj: | Journal of Clinical & Experimental Oncology. |
| ISSN: | 2324-9110 |
| Popis: | Background: Oxidation products are assumed to play essential role in the pathogenesis of benign and malignant diseases of the thyroid. Objective: The aim of this prospective study is to examine advanced oxidation protein products (AOPP), lipid peroxidation product malonyldialdehyde (MDA), ferrous oxidation in xylenol orange (FOX) and the antioxidant enzyme activity of superoxide dismutase (SOD) in blood samples of multinodular goiter and papillary thyroid cancer patients before and after thyroidectomy and compare them to healthy controls. Methods: Thirty-seven papillary thyroid cancer and 43 benign multinodular goiter patients treated with total thyroidectomy and 35 healthy control subjects were included in this study. AOPP, FOX, MDA, and SOD levels were studied before and after thyroidectomy to determine oxidation products and antioxidant enzyme activities. Results: Before thyroidectomy, serum levels of AOPP, FOX, and MDA were significantly higher in both benign and malignant patient groups compared to control group (p |
| Databáze: | OpenAIRE |
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