Detection of trastuzumab (T) level in human serum using quartz crystal microbalance (QCM) piezo-immunosensors by immobilization of a HER2 mimotope-derived synthetic peptide and its potential application in breast cancer

Autor:	Alaa Muslimani, Raymond L. Mernaugh, Pankaj R. Singh, Yuqin Shang, Mohammad Muhsin Chisti, Ishmael Jaiyesimi, Xiangqun Zeng
Rok vydání:	2012
Předmět:	chemistry.chemical_classification Cancer Research Chromatography biology Mimotope medicine.drug_class business.industry Peptide Quartz crystal microbalance Monoclonal antibody Oncology Antigen chemistry Trastuzumab medicine biology.protein Antibody business Receptor medicine.drug
Zdroj:	Journal of Clinical Oncology. 30:628-628
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2012.30.15_suppl.628
Popis:	628 Background: Varied clinico-pathological response to monoclonal antibodies like T has been reported either due to presence of antibodies, rapid clearance or low density of target receptor/antigens. This demands need for an assay to monitor serum T therapeutic levels to ensure appropriate dosage. Enzyme-linked immunosorbent assay (ELISA) is still the most widely used technique to detect T level in human serum which is expensive and time consuming. For the first time, we established a platform to detect T level by using a small (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bdbf3c490facf4b7d9fe7c447a59fcf4 https://doi.org/10.1200/jco.2012.30.15_suppl.628 Zobrazit plný text záznamu