Ecteinascidia turbinataExtract Activates Components of Inflammatory Responses Throughout the Phylogenetic Spectrum
| Autor: | Edgar M. Huggins, M. Michael Sigel, James A. Hightower, Steven S. Hayasaka, Larry J. Mccumber, James F. Davis |
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| Rok vydání: | 1983 |
| Předmět: |
biology
Lymphocyte medicine.medical_treatment Phagocytosis Intraperitoneal injection Inflammation Ecteinascidia turbinata biology.organism_classification In vitro Microbiology medicine.anatomical_structure In vivo Immunology medicine General Earth and Planetary Sciences Cytotoxic T cell medicine.symptom General Environmental Science |
| Zdroj: | American Zoologist. 23:221-227 |
| ISSN: | 0003-1569 |
| Popis: | The tunicate Ecteinascidia turbinata contains a substance or substances capable of exerting a number of biological effects. Extracts of tunicate tissues have been shown to kill tumor cells in vitro and arrest tumor growth in vivo . The extracts also suppress allograft rejection, graft- US .-host reactions and lymphocyte proliferative responses as well as humoral responses to immunization. By modifying the conditions, the extracts could potentiate antibody responses. In addition, they augment functions of monocyte-macrophages as evidenced by in vitro phagocytosis, in vivo clearance, and cytotoxic activity against target cells. After studies in mice, we were able to demonstrate that the extracts could activate the phagocytic systems of shrimp, blue crab, and fish (the American eel). In fish, the intraperitoneal route was superior to the intravenous route for promotion of phagocytosis, increase in percent presentation of granulocytes and for enhancement of resistance to bacterial infection. Intrarriuscular and intraperitoneal injection led to local inflammation with accumulation of granulocytes and macrophages. |
| Databáze: | OpenAIRE |
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