Cardiovascular remodeling as a result of fibroblast growth factor-23 (FGF-23)/Klotho imbalance in patients with CKD

Autor:	Mikhail Ratanov, Vasiliy Kozlov, M V Taranova, Lidia Lysenko, V. D. Beketov, Alexey V Volkov, Svetlana Milovanova, Ludmila Milovanova, Anastasia I Pasechnik
Rok vydání:	2021
Předmět:	Fibroblast growth factor 23 education.field_of_study medicine.medical_specialty business.industry Urology Population Left ventricular hypertrophy medicine.disease Blood pressure Nephrology Internal medicine Troponin I Cardiology Medicine education business Klotho Pulse wave velocity Kidney disease
Zdroj:	International Urology and Nephrology. 54:1613-1621
ISSN:	1573-2584
Popis:	BACKGROUND In chronic kidney disease (CKD) cardiovascular remodeling (CVR) is very frequent compared with general population and, as suppose, may be associated with «new» renal risk factors. The aim of study was to estimate association of new serum biomarkers (FGF-23, Klotho) and traditional biomarker of cardiac damage-serum Troponin I (sTr-I) with signs of CVR. METHODS One hundred thirty CKD G1-5D patients without cardiovascular disease (CVD) clinical manifestation were included. We measured serum FGF-23, Klotho and sTr-I. The instrumental methods were: echocardiography, SphygmoCor test [Pulse Wave Velocity (PWV), Central (aortic) Blood Pressure (CBP), Subendocardial Blood Supply (SBS)]. RESULTS FGF-23 level correlated with: sTr-I (r = 0.512; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bdb43ca7d25e49ac81020ed0dddef34f https://doi.org/10.1007/s11255-021-03046-8 Zobrazit plný text záznamu Full text from SpringerLink