Executive Dysfunction in Homebound Older People with Diabetes Mellitus

Autor:	Richard D. Siegel, Drew Leins, Paul Summergrad, Wei Qiao Qiu, Lauren Collins, Irwin H. Rosenberg, Xiaoyan Sun, Katherine L. Tucker, Patricia L. Hibberd, Lauren Smaldone, Lixia Wang, Jacqueline Yee, Lori Lyn Price, Jennifer S. Buell, David Mkaya Mwamburi, Carey Wagner, Marshal F. Folstein, Tammy Scott
Rok vydání:	2006
Předmět:	Geriatrics Gerontology medicine.medical_specialty education.field_of_study Pediatrics Activities of daily living business.industry Cognitive disorder Population Disease medicine.disease Homebound Persons Diabetes mellitus medicine Geriatrics and Gerontology business education Executive dysfunction
Zdroj:	Journal of the American Geriatrics Society. 54:496-501
ISSN:	1532-5415 0002-8614
DOI:	10.1111/j.1532-5415.2005.00632.x
Popis:	OBJECTIVES: To describe patterns of cognitive deficits and activities of daily living (ADLs) in older people with diabetes mellitus. DESIGN: Cross-sectional, population-based study. SETTING: Three homecare agency areas in Boston, Massachusetts. PARTICIPANTS: Two hundred ninety-one homebound people aged 60 and older; 40% with diabetes mellitus. MEASUREMENTS: Demographic data; evidence of diabetes mellitus and other diseases; Mini-Mental State Examination and tests of memory and executive function; ADLs. RESULTS: Executive and visuospatial functions were more impaired in individuals with diabetes mellitus than in those without, as assessed using Block Design (mean score±standard deviation 17.1±8.6 vs 20.5±9.6, P=.003) and Trails B (median seconds to accomplish the task: 255 vs 201, P=.03). For memory, word retention score was lower in those with diabetes mellitus than without (39.1±28.9 vs 48.0±29.7, P=.01), but the other memory tests did not show a difference between these two subgroups. More individuals with diabetes mellitus suffered from depressive symptoms than those without (55% vs 42%, P=.03). The ADL scores of those with diabetes mellitus were higher than those without. CONCLUSION: The pattern of cognitive deficits in people with diabetes mellitus suggests frontal-subcortical dysfunction, as seen in microvascular disease of the brain. The impairment in ADLs may be associated with this executive dysfunction, which cerebral microvascular disease in diabetes mellitus may cause.
Databáze:	OpenAIRE
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