Polyhydroxylated Pyrrolidines: Synthesis of Trideoxy-2,5-iminohexitols

Autor:	Isidoro Izquierdo, María T. Plaza, Fernando Sánchez-Cantalejo, Daniele Lo Re, Juan A. Tamayo
Rok vydání:	2008
Předmět:	chemistry.chemical_compound chemistry biology Stereochemistry Organic Chemistry Glycosyltransferase biology.protein Combinatorial chemistry Catalysis Pyrrolidine
Zdroj:	Synthesis. 2008:1373-1378
ISSN:	1437-210X 0039-7881
Popis:	A series of naturally occurring pyrrolidine alkaloids and analogues, with the general structure of trideoxy-2,5-iminohexitols (imino- or azasugars), have been enantiosynthesized using triorthogonally protected pyrrolidines, previously prepared from commercial D-fructose, as homochiral starting materials. The inhibitory activity of some of the described compounds against glycosidases and glycosyltransferases makes them potential therapeutic agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bda156da6ba77c0eb41e8df771689620 https://doi.org/10.1055/s-2008-1072566 Zobrazit plný text záznamu