Identifying the links between obesity, insulin resistance and β-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes
| Autor: | Andrew S. Greenberg, M. L. McDaniel |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Clinical Biochemistry Type 2 Diabetes Mellitus Adipose tissue General Medicine Type 2 diabetes Biology medicine.disease Biochemistry Endocrinology Insulin resistance Internal medicine Diabetes mellitus medicine Glucose homeostasis Thiazolidinedione Epigenetics of diabetes Type 2 |
| Zdroj: | European Journal of Clinical Investigation. 32:24-34 |
| ISSN: | 0014-2972 |
| Popis: | A combination of insulin resistance and pancreatic beta-cell dysfunction underlies most cases of type 2 diabetes. While the interplay of these two impairments is believed to be important in the development and progression of type 2 diabetes, the mechanisms involved are unclear. A number of factors have been suggested as possibly linking insulin resistance and beta-cell dysfunction in the pathogenesis of type 2 diabetes mellitus. Pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-alpha) have deleterious effects on both glucose homeostasis and beta-cell function, and can disrupt insulin signalling pathways in both pancreatic beta cells and liver and adipose tissue. The anti-inflammatory activity of the thiazolidinedione anti-diabetic agents is potentially beneficial, given the possible role of pro-inflammatory cytokines in linking insulin resistance with beta-cell dysfunction. |
| Databáze: | OpenAIRE |
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