Histopathological prognosis of papillary thyroid carcinoma associated with nutritional status of vitamins A and E

Autor: Julianna Lys de Sousa Alves Neri, Karla Danielly da Silva Ribeiro, Diego Marques da Costa Santos, Sheila Ramos de Miranda Henriques Tarrapp, Ana Gabriella da Costa Lemos Silva, Thaisa Cristina Tavares de Melo, Vivian Nogueira Silbiger, Nathália Kelly de Araújo, Isabela Samária Fernandes Leite, Lara Lima-Antoine, Carlos Ramos, Jéssica Nayara Góes de Araújo, André Ducati Luchessi, Clélia de Oliveira Lyra
Rok vydání: 2021
Předmět:
Zdroj: European Journal of Clinical Nutrition. 76:469-476
ISSN: 1476-5640
0954-3007
DOI: 10.1038/s41430-021-00976-5
Popis: Background/objectives Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status of vitamins A and E (serum levels and dietary intake) and histopathological outcomes in Papillary Thyroid Carcinoma (PTC) patients. Subjects/methods We applied a cross-sectional study (2017-2018) and quantified retinol (ROH) and α-tocopherol (TOH) serum levels and vitamins dietary intake of 46 PTC patients. Serum vitamins were quantified by high efficiency liquid chromatography and vitamins dietary intake was analyzed by 24-hr dietary recalls. Results Patients with lower ROH serum levels were more likely to present lymph node metastasis and/or angiolymphatic invasion (p = 0.025). In addition, higher vitamin A and vitamin E intake are related to the absence of extrathyroidal extension (p = 0.013) and lymph node metastasis (p = 0.007), respectively. Our findings suggest that a ROH serum level greater than 2.65 μmol/L in PTC patients may be a protective factor against the presence of lymph node metastasis and angiolymphatic invasion. In addition, vitamin A and E intake may protect against extrathyroidal extension and lymph node metastasis. Conclusions A favourable nutritional status (higher serum levels and/or intake) of vitamin A and E may be associated with less aggressive tumours in PTC patients.
Databáze: OpenAIRE
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