Stability Indicating RP-HPLC Method for Determination of Tolterodine in Solid Dosage Form

Autor:	Arumugam Karthik, Udupa Nayanabhirama, SG Vasantharaju, Mishra Akanksha, Krishnamoorthy Bhat, Musmade P. Prashant
Rok vydání:	2009
Předmět:	Chromatography Potassium Analytical chemistry chemistry.chemical_element Linearity High-performance liquid chromatography Dosage form Volumetric flow rate chemistry.chemical_compound chemistry medicine Tolterodine Acetonitrile Stock solution medicine.drug
Zdroj:	Journal of Pharmaceutical Research. 8:184
ISSN:	2454-8405 0973-7200
Popis:	A simple, rapid, and accurate RP-HPLC method was developed for the determination of tolterodine in solid pharmaceutical dosage form. The method showed a linear response for concentration in the range of 1-15μg/ml using acetonitrile:potassium dihydrogen phosphate (50:50,v/v) as the mobile phase with detection at 284 nm and a flow rate of 1ml/min. The method was statistically validated for accuracy, precision, linearity, range, robustness, and stock solution stability. Recovery studies of the dosage form were also carried out and the mean recovery was found to be 98.35±1.01 %. Due to the simplicity, rapidity, and accuracy the method could be used for routine quality control analysis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd8baedfb276a4bcc582684f4a6cf13b https://doi.org/10.18579/jpcrkc/2009/8/4/79683 Zobrazit plný text záznamu