| Popis: |
The issues of studying the mechanisms of skin aging continue to be relevant, due to the intensive development of cosmetology and various methods for restoring physiological parameters after destructive violations of the integrity of the skin. Skin aging due to internal and external factors can significantly change the structure and function of the epidermis and dermis, and may be associated with a large number of complications in various dermatological conditions, in that senescent dermal fibroblasts modify the tissue microenvironment through changes in their cellular factors and extracellular matrix. The paper presents data on the normal structure of the skin, the features of its vascularization, a review of the literature on the influence of various factors of the external and internal environment on the structure of the skin, taking into account age-related features, summarizes the structural changes in the skin in the age aspect, the main molecular mechanisms that explain these changes. Numerous studies confirm that skin aging is caused by a complex effect of various factors that are associated both with a change in the physiological mechanisms of regulation of the processes of the intracellular and extracellular matrix, and with the influence of environmental conditions. |
