Two-pot synthesis and photophysical studies of 1,6-disubstituted 5-aza-indoles from succinaldehyde and N-aryl propargylic-imines

Autor:	Sravendra Rana, Amol Prakash Pawar, Satheeshvarma Vanaparthi, Mamta Mamta, Indresh Kumar, Eldhose Iype, Jyothi Yadav
Rok vydání:	2021
Předmět:	Annulation chemistry.chemical_compound Succinaldehyde Aqueous solution chemistry Aryl Organic Chemistry Physical and Theoretical Chemistry Biochemistry Combinatorial chemistry
Zdroj:	Organic & Biomolecular Chemistry. 19:10601-10610
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d1ob01949j
Popis:	A two-pot synthesis of 5-aza-indoles has been developed from aqueous succinaldehyde and N-aryl propargylic-imines. This overall protocol involves (i) metal-free [3+2] annulation between aqueous succinaldehyde and N-aryl propargylic-imines to access 2-alkynyl-pyrrole-3-aldehydes, (ii) Ag-catalyzed 6-endo-dig-cyclization to get substituted 5-aza-indoles in the second pot. The 5-aza-indoles showed engaging photophysical activities, and reaction practicality has been demonstrated for the pot-economic gram-scale synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd888278451797ea0018f7780716aca4 https://doi.org/10.1039/d1ob01949j Zobrazit plný text záznamu