ULTRAFILTRATION OF ANTERIOR PITUITARY KETOGENIC AND GROWTH PRINCIPLES
| Autor: | Reginald A. Shipley, W. B. Seymour |
|---|---|
| Rok vydání: | 1942 |
| Předmět: | |
| Zdroj: | Endocrinology. 31:634-637 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-31-6-634 |
| Popis: | MAGISTRIS (i), Anselmino and Hoffman (i), and Denstedt, O'Donovan and Neufeld (3) have reported that the ketogenic principle of the anterior pituitary is ultrafiltrable. Shipley and Long (4) and Greaves, Freiberg, and Johns (5), however, could not demonstrate ketogenic activity in ultra-filtrates which had been obtained with collodion membranes. Evidence concerning pituitary growth hormone is also conflicting, for although this substance is thought to be a protein, Van Dyke and Wallen-Lawrence (6), employing a collodion barrier, reported one experiment in which activity was present in the dialyzate from an extract. Ultrafiltrable substances are sometimes defined as those which will permeate membranes which retain proteins but admit substances of smaller molecular size. The term ultrafiltrable, however, has no such precise meaning for it is possible to prepare filters which retain not only molecules of protein but also those of smaller dimension, and, in turn, certain membranes will admit proteins of small... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|