| Popis: |
The production of reactive oxygen species (ROS) takes place in all organisms. ROS regulate the cell cycle and other biological phenomena that make them essential for life. However, when there is a ROS excess and/or the antioxidant system is reduced, oxidative stress is induced. During this process, ROS can attack various biomolecules and generate oxidative damage. The hydroxyl radical is a highly reactive ROS that can react with guanine in deoxyribonucleic acid (DNA), generating the molecule 8-hydroxy-2’-deoxyguanosine (8-OHdG), a marker of oxidative damage to DNA. Some research have shown that cancer patients or mouse models of cancer have elevated levels of 8-OHdG in serum, urine, saliva, and tissues. This literature review summarizes the main findings of 8-OHdG in several types of cancer and shows the evidence for the potential use of 8-OHdG as a biomarker of oxidative DNA damage in cancer. |
