Juvenile dermatomyositis: A review of clinical features and management

Autor:	Shabina Habibi, Athimalaipet V Ramanan
Rok vydání:	2012
Předmět:	medicine.medical_specialty Pathology Proximal muscle weakness business.industry Disease medicine.disease Dermatology Rash Pathogenesis Rheumatology Calcinosis Medicine Methotrexate medicine.symptom Lipodystrophy business Juvenile dermatomyositis medicine.drug
Zdroj:	Indian Journal of Rheumatology. 7:80-86
ISSN:	0973-3698
DOI:	10.1016/s0973-3698(12)60032-6
Popis:	Juvenile dermatomyositis is the most common of the idiopathic inflammatory myositis of childhood. It is characterised by a pathognomic skin rash along with proximal muscle weakness. It may also affect organs other than the muscle and skin. Calcinosis and lipodystrophy are complications of long-standing untreated or poorly treated disease, associated with chronic morbidity. A variety of environmental and genetic risk factors are implicated in its pathogenesis. Up-regulation of genes by type-I interferon appears central. Corticosteroids along with methotrexate are the mainstay of therapy. Disease outcome is in general good.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd77a5275cc102ece957a3cd697c3be7 https://doi.org/10.1016/s0973-3698(12)60032-6 Zobrazit plný text záznamu