Antimicrobial indolequinones from the mid-intestinal gland of the muricid gastropod Drupella fragum

Autor:	Mitsuaki Kodama, Kozo Shibata, Masamitsu Ochi, Yoshiyasu Fukuyama, Chie Iwatsuki, K. Kataoka
Rok vydání:	1998
Předmět:	biology Chemistry Organic Chemistry Bacillus subtilis medicine.disease_cause biology.organism_classification Antimicrobial Biochemistry Microbiology Indolequinones medicine.anatomical_structure Staphylococcus aureus Intestinal gland Drug Discovery medicine Drupella fragum Escherichia coli
Zdroj:	Tetrahedron. 54:10007-10016
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(98)00593-6
Popis:	Three new indolequinones, 6-methoxyindole-4,7-quinone (1), 5-methoxyindole-4,7-quinone (2) and 5-methylindole-4,7-quinone (3) were isolated from the mid-intestinal gland of the muricid gastropod Drupella fragum. The structures of 1 and 2 were established by spectroscopic methods and total synthesis, whereas the structure of 3 was elucidated mainly by NMR spectroscopic analyses. Compounds 1 ∼ 3 exhibited moderate antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, and Escherichia coli with MIC = 6.25 ∼ 50 μg/mL.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd72941df953d92a12eb7413cfda839f https://doi.org/10.1016/s0040-4020(98)00593-6 Zobrazit plný text záznamu Full Text from ScienceDirect