Toxicity of p-Aminobenzoic Acid
| Autor: | E. B. Robbins, C. C. Scott |
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| Rok vydání: | 1942 |
| Předmět: | |
| Zdroj: | Experimental Biology and Medicine. 49:184-186 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-49-13507 |
| Popis: | Summary1. In mice, rats, and dogs, the acute toxicity of p-aminobenzoic acid by mouth has been determined. The drug is more toxic to mice and dogs than to rats. By intravenous injection the sodium salt of p-aminobenzoic acid is more toxic to rats than to mice. 2. Oral doses of p-aminobenzoic acid greater than 1.0 g per kg to dogs may cause death accompanied by acute gastro-enteritis and hemorrhages into the small intestine. Acute necrosis of the liver may result from doses of 2.0 g per kg or larger. 3. Rats tolerate daily doses of 1.4 g per kg by mouth for about a month without inhibition of growth or pathological changes. |
| Databáze: | OpenAIRE |
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