Absent Hypoxic and Hypercapneic Arousal Responses in Children With Myelomeningocele and Apnea

Autor:	Bruce G. Nickerson, Antonio M. Rodriguez, Robert A. Jacobs, Sally L. Davidson Ward, Andre L. van der Hal, Thomas G. Keens
Rok vydání:	1986
Předmět:	Spirometry medicine.diagnostic_test business.industry Decompression medicine.medical_treatment Apnea Hypoxia (medical) respiratory tract diseases Arousal Hypoventilation Tracheotomy Anesthesia Pediatrics Perinatology and Child Health Medicine Respiratory system medicine.symptom business
Zdroj:	Pediatrics. 78:44-50
ISSN:	1098-4275 0031-4005
DOI:	10.1542/peds.78.1.44
Popis:	Hypoxic and hypercapneic arousal responses from quiet sleep were tested in seven infants with myelomeningocele and Arnold-Chiari malformation who were symptomatic with apnea and/or hypoventilation. All infants with myelomeningocele required tracheostomy and posterior fossa decompression. Responses were compared with those of nine healthy control infants. To assess hypoxic arousal, inspired Po2 was decreased until the end-tidal (alveolar) Po2 reached 45 mm Hg for a maximum of three minutes. Eleven studies were performed in seven infants with myelomeningocele, and arousal occurred in only two studies (18.2%). Eight of nine control infants aroused to hypoxia (89%). To test hypercapneic arousal, inspired Pco2 was increased until end-tidal Pco2 reached 60 mm Hg for a maximum of three minutes. Eight studies were performed on six infants with myelomeningocele, and arousal occurred in three studies (37.5%). All seven control infants studied aroused to hypercapnea (100%). Three infants with myelomeningocele subsequently died. Infants with myelomeningocele, Arnold-Chiari malformation, and apnea or hypoventilation have arousal deficits to respiratory stimuli.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd5e81167fa30f37b59448fcdb082c5b https://doi.org/10.1542/peds.78.1.44 Zobrazit plný text záznamu