| Autor: |
John S. Thompson, Donald E. Hricik, C. Martin Bunke, Mark D. Pescovitz, Raymond Pollak, M. Gerry Choc, David I. Min, Eva M. Vasquez, James B. Stinson, Judy Hyun Ju Jin, Jon B. Klein, Christopher L. Marsh, R. Wong, Duane G. Wombolt, Thomas Waid, Timothy L. Pruett, Gary Barone |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
Transplantation. 61:968-970 |
| ISSN: |
0041-1337 |
| DOI: |
10.1097/00007890-199603270-00021 |
| Popis: |
A 12-week, randomized, double-blind, multicenter pharmacokinetic study was conducted to compare the clinical safety and tolerability of cyclosporine capsules and oral solution for microemulsion and cyclosporine in 101 primary renal transplant recipients. Cyclosporine emulsion has more complete absorption and improved bioavailability compared with cyclosporine, and dosing of both cyclosporine formulations was adjusted to achieve comparable whole-blood trough levels. Mean serum creatinine values were higher in the cyclosporine emulsion group at baseline, 8, and 12 weeks (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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