Observations on cation-binding characteristics and nuclear magnetic resonance spectra of the N-carboxymethyl and N-acetyl analogs of heparin

Autor:	Rabindra N. Rej, Kevin R. Holme, Arthurs. S. Perlin
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Cation binding Organic Chemistry Charge density General Chemistry Heparin Polymer Catalysis Spectral line Ion Paramagnetism Nuclear magnetic resonance chemistry medicine Spectroscopy medicine.drug
Zdroj:	Canadian Journal of Chemistry. 68:1740-1745
ISSN:	1480-3291 0008-4042
Popis:	Based on the observed paramagnetic relaxation effects of Cu2+ and Fe3+ ions and the chemical shift displacements induced by Ca2+ ions, nuclear resonance spectroscopy has been used to compare cation-binding characteristics of heparin with those of its N-carboxymethyl and N-acetyl analogs and related polyanions. Heparin is unique in exhibiting a high affinity for all three cations. Among the other polymers, binding selectivities differ notably. Such factors as the incidence and distribution of anionic charges are discussed. The preparation of the N-carboxymethyl analog of heparin is described, and 1H and 13C nuclear magnetic resonance spectroscopic data are reported for it, as well as for the N-acetyl analog. Keywords: heparin, N-carboxymethyl analog, N-acetyl analog, cation binding, ion-selectivity, anionic charge distribution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd571d40beaa8f6d46f73cc4fb1259e2 https://doi.org/10.1139/v90-270 Zobrazit plný text záznamu