Basal and LH-RH-stimulated gonadotropin secretion in oophorectomized female rats with streptozotocin-induced diabetes
| Autor: | Peryshkova Ta, Adamskaia Ei, Babichev Vn |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
endocrine system
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Streptozotocin Gonadotropic cell medicine.disease Gonadotropin secretion Basal (phylogenetics) Endocrinology Internal medicine Diabetes mellitus medicine Ovariectomized rat Reproductive system business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Problems of Endocrinology. 40:43-46 |
| ISSN: | 2308-1430 0375-9660 |
| DOI: | 10.14341/probl11331 |
| Popis: | In vitro insulin effect on basal and LH-RH- stimulated gonadotropin secretion in oophorectomized female rats with streptozotocin diabetes administered estradiol as replacing hormone therapy was studied. The results were compared to those obtained after a similar incubation of adenohypophyses of oophorectomized rats and of oophorectomized rats administered estradiol. Estradiol was found to change the type of LH-RH-stimulated gonadotropin secretion in oophorectomized animals. Basal, but not LH-RH-stimulated gonadotropin secretion, was increased in rats with experimental diabetes as against other groups. Insulin inhibited basal and increased LH-RH-stimulated gonadotropin secretion in oophorectomized rat’s with streptozotocin diabetes administered estradiol. A conclusion is made about impaired sensitivity of hypophyseal gonadotrophs to LH-RH in streptozotocin diabetes and about a possible contribution of insulin to regulation of body reproductive system at the level of hypophysis. |
| Databáze: | OpenAIRE |
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