Rare Site Hepatocellular Carcinoma Metastasis
| Autor: | Andres Muñoz, Ana Santafe, Araceli Mayol, Juan Carlos Pastor, Enrique Boldo, Alba Coret, Rafael Lozoya, Carlos Fortea-Sanchis, Diana Escribano, Nuria Bosch, Guillermo Perez de Lucia |
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| Rok vydání: | 2020 |
| Předmět: |
Sorafenib
Oncology medicine.medical_specialty medicine.diagnostic_test Sunitinib business.industry medicine.medical_treatment Context (language use) medicine.disease digestive system diseases Metastasis Radiation therapy Capecitabine Internal medicine Hepatocellular carcinoma Biopsy medicine business medicine.drug |
| Zdroj: | Journal of Hepatocellular Carcinoma. 7:39-44 |
| ISSN: | 2253-5969 |
| DOI: | 10.2147/jhc.s238963 |
| Popis: | Introduction Besides more common sites such as lung or peritoneum, hepatocellular carcinoma (HCC) can metastatize to rare sites. We report herein a new metastatic site of HCC: the nail-bed. We also review other recently reported rare site HCC metastases (RSHM). Case report A 66-year-old woman with a 12-year history of resected-stage IA HCC who later presented lung, spleen and brain metastases treated with surgery, systemic therapies (sorafenib, sunitinib, capecitabine) and radiotherapy. The patient was referred to us because of a painful and rapidly evolving mass in the nail-bed of the left thumb. Biopsy confirmed nail-bed HCC metastasis, and the finger was amputated. The patient died few weeks later. Conclusion This case was an opportunity for us to review RSHM. This type of metastasis seems to be an early event, in the context of advanced stage HCC with elevated protein induced by vitamin K absence-II (PIVKA II). The Lee nomogram is useful in detecting patients at high risk of developing RSHM. We would suggest insisting on systemic treatment in these metastatic patients although overall survival after RSHM diagnosis is poor. |
| Databáze: | OpenAIRE |
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