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It is generally accepted that giant follicular lymphoma (Brill-Symmers) belongs to the follicular variety (follicular lymphoma) of malignant lymphomas (Rappaport, Winter and Hicks, 1956). Neither the follicular, nor the more common diffuse variety represent clinical and pathological entities. The nodular architectural pattern itself is by no means characteristic and permits no further classification. If, however, the cytological composition of the follicles is considered, characteristic differences become evident. According to the predominant cell-type, Rappaport distinguish five groups of follicular lymphoma (Table 1). |
