ChemInform Abstract: Organocatalytic Enantioselective Mannich-Type Reaction of Phosphorus Ylides: Synthesis of Chiral N-Boc-β-Amino-α-methylene Carboxylic Esters

Autor:	Yankai Liu, Tai-Ran Kang, Yan Zhang, Ying-Chun Chen, Ze-Kai Hu
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Aldimine chemistry.chemical_compound Chemistry Phosphorus Organocatalysis Enantioselective synthesis chemistry.chemical_element Organic chemistry General Medicine Methylene
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200829080
Popis:	The first asymmetric Mannich-type reaction of stabilized phosphorus ylides and N-Boc aldimines was described promoted by a readily available and recyclable chiral bisthiourea organocatalyst. Subsequent reaction with formalin smoothly provides N-Boc-β-amino-α-methylene carboxylic esters in a highly enantiomerically enriched form (up to 96% ee).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd4354c5030f938e501abbe7f77173f3 https://doi.org/10.1002/chin.200829080 Zobrazit plný text záznamu Plný text