New hypervalent iodine reagents for electrophilic trifluoromethylation and their precursors: synthesis, structure, and reactivity

Autor:	Antonio Togni, Ján Cvengroš, Katrin Niedermann, Philip Battaglia, Jan M. Welch, Nico Santschi, Raffael Koller
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Trifluoromethylation Chemistry Organic Chemistry Hypervalent molecule Cationic polymerization Biochemistry Chemical synthesis Heterocyclic compound Drug Discovery Electrophile Molecule Organic chemistry Reactivity (chemistry)
Zdroj:	Tetrahedron. 66:5753-5761
ISSN:	0040-4020
DOI:	10.1016/j.tet.2010.04.125
Popis:	Several new five- and a six-membered heterocyclic monochloroiodanes, including two cationic species, were synthesized. Three of which were used for the preparation of corresponding trifluoromethylation reagents. These compounds were characterized by X-ray crystallography for a comparative structural study. A reactivity study on the trifluoromethylation of para-toluenesulfonic acid has been conducted in order to compare initial rates. Compounds having a longer I–O bond display a higher reactivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::bd3b83a63eb9358a506f83010491ebcd https://doi.org/10.1016/j.tet.2010.04.125 Zobrazit plný text záznamu Full Text from ScienceDirect