Kinase bypass: A new strategy for anti-HIV drug design
| Autor: | Derek Kinchington, Christopher McGuigan, Timothy J. O'Connor, Caleb Nickson, S. R. Nicholls |
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| Rok vydání: | 1993 |
| Předmět: |
Kinase
Organic Chemistry Clinical Biochemistry Human immunodeficiency virus (HIV) Pharmaceutical Science Phosphate medicine.disease_cause Biochemistry chemistry.chemical_compound Mechanism of action chemistry Drug Discovery medicine Anti-hiv drugs Molecular Medicine medicine.symptom Thymidine Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:1207-1210 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(00)80316-9 |
| Popis: | The 5′-bis(trichloroethyl) phosphate derivatives of several 3′-O-acyl thymidines were prepared from the thymidine phosphate. Even though the parent nucleosides are inactive as antiviral agents, the phosphates are selective inhibitors of the proliferation of HIV. This activity is attributed to a new mechanism of action, we herein describe as “kinase by-pass”. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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