A Novel Function of Prolactin-Releasing Peptide in the Control of Growth Hormone via Secretion of Somatostatin from the Hypothalamus1
| Autor: | Yoshitaka Tamada, Yasuhiko Ibata, Yuko Kataoka, Norio Iijima, Takanori Yamamoto, Kenshi Kakihara, Hirokazu Matsumoto, Nobuhiro Suzuki, Yoshio Matsumoto, Shuji Hinuma, Masaki Tanaka, Takahiko Yano |
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| Rok vydání: | 2001 |
| Předmět: |
Prolactin-releasing hormone
medicine.medical_specialty Prolactin-releasing peptide In situ hybridization Biology Somatropin Endocrinology Somatostatin medicine.anatomical_structure nervous system Anterior pituitary Hypothalamus Internal medicine medicine Periventricular nucleus hormones hormone substitutes and hormone antagonists |
| Zdroj: | Endocrinology. 142:3239-3243 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo.142.7.8257 |
| Popis: | The present study examined a novel function of PRL-releasing peptide (PrRP) on the neuroendocrine. PrRP-immunoreactive nerve fibers and nerve terminals were located in the vicinity of the somatostatin (SOM)-neurons in the hypothalamic periventricular nucleus (PerVN). Immuno-electron microscopy revealed that PrRP-immunoreactive nerve terminals made synaptic contacts with nonimmunoreactive neuronal elements in the PerVN. Intracerebroventricular (icv) administration of PrRP induced immediate early gene, NGFI-A, in SOM-neurons in the PerVN. Double-labeling in situ hybridization showed that some parts of SOM-neurons in the PerVN expressed PrRP receptor messenger RNA. Therefore, some parts of SOM-neurons in the PerVN are considered to be directly innervated by PrRP via PrRP receptor. In addition to the above morphological characteristics, icv administration of PrRP decreased plasma GH levels. Such inhibitory effects of PrRP on the secretion of GH from the anterior pituitary were diminished by depletion or neutr... |
| Databáze: | OpenAIRE |
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