Estimating Urea Clearance in Patients on Continuous Ambulatory Peritoneal Dialysis: A Multivariate Analysis
| Autor: | N Nicolopoulou, A Dimitriadis, Antonios H. Tzamaloukas, Glen H. Murata, Elias V. Balaskas, S Voudiklari, Nicholas Dombros |
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| Rok vydání: | 1998 |
| Předmět: |
Multivariate statistics
medicine.medical_specialty medicine.medical_treatment Body water 030232 urology & nephrology Biomedical Engineering Urology Medicine (miscellaneous) Renal function Bioengineering 030204 cardiovascular system & hematology Peritoneal dialysis Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Linear regression medicine Intensive care medicine Dialysis Creatinine business.industry Continuous ambulatory peritoneal dialysis General Medicine chemistry business |
| Zdroj: | The International Journal of Artificial Organs. 21:515-520 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/039139889802100909 |
| Popis: | The purpose of this study was to determine if Kt/V urea in continuous ambulatory peritoneal dialysis (CAPD) could be estimated by a multivariate model based upon simple clinical observations. The study included 439 clearance studies in 301 CAPD patients followed in 8 dialysis centers. Weekly urea clearance, 24 h urine volume and 24 h drain volume were normalized to body water by the formulae of Watson (Kt/V, UV/V, and DV/V respectively). Adequate dialysis was defined as Kt/V ≥2.0 weekly. Subjects at 2 units were used to derive the models, while others were used for model validation. Stepwise multiple linear regression was performed on the derivation set (DS) to identify the clinical variables that correlated with Kt/V. The model was then used to estimate Kt/V for the validation set (VS). In the DS, 110 clearance studies were performed in subjects with residual renal function. Multiple linear regression showed that weekly Kt/V was defined by the expression: Kt/V = 1.48 + 24.1 (UV/V) + 2.92(DV/V) - 0.049 (serum creatinine) (r=0.750, p2.3 weekly (7.9%, 54.7% and 79.7%, respectively; p2.3 weekly (8.1%, 68.8%, and 100%, respectively; p |
| Databáze: | OpenAIRE |
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