Heat shock responsive drug delivery system based on mesoporous silica nanoparticles coated with temperature sensitive gatekeeper
| Autor: | Man Kyu Shim, Jong Ho Kim, Min Ju Park, Bom Jung, Han Chang Kang, Eun Hyang Jang, In Hye Cho |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
animal structures
Biocompatibility Nanoparticle Nanotechnology macromolecular substances 02 engineering and technology 010402 general chemistry 01 natural sciences PEG ratio polycyclic compounds medicine General Materials Science Doxorubicin Cytotoxicity Chemistry technology industry and agriculture General Chemistry Mesoporous silica 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Mechanics of Materials Shock (circulatory) Drug delivery Biophysics sense organs medicine.symptom 0210 nano-technology medicine.drug |
| Zdroj: | Microporous and Mesoporous Materials. 253:96-101 |
| ISSN: | 1387-1811 |
| DOI: | 10.1016/j.micromeso.2017.06.042 |
| Popis: | Mesoporous silica nanoparticles (MSN) have several advantages as carriers for drug delivery, including high drug loading capacity, good biocompatibility, excellent stability, and easily tailorable surface properties. This study describes the design of an MSN-based carrier for use in a heat shock responsive drug delivery system. MSN were functionalized with the temperature-sensitive PEG/PCL multiblock copolymer, as gatekeepers, allowing the release of entrapped drugs in response to heat shock stimuli (MBC-MSN). In the absence of heat shock, doxorubicin (Dox)-loaded MBC-MSN showed very low cytotoxicity, as PEG/PCL inhibited the premature release of Dox from MBC-MSN. In response to heat-shock stimuli, however, these Dox@MBC-MSN showed significant cytotoxicity, similar to that of free Dox. Dox release was due to the loosening of the structure of the gatekeeper, PEG/PCL, in response to the heat shock stimuli. Taken together, these findings suggest that MBC-MSN are a strong candidate to act as a carrier in heat shock responsive drug delivery. |
| Databáze: | OpenAIRE |
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