Features of pathological anatomy of lungs at COVID-19
| Autor: | O. D. Mishnev, LM Mikhaleva, E. A. Pershina, Mikhaylichenko, K. Yu, Chernyak, A. V., D. V. Kalinin, AL Chernyaev, Z. R. Omarova, O. V. Zayratyants, V. V. Varyasin, O. A. Tishkevich, S. A. Vinogradov, M. V. Samsonova |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
2019-20 coronavirus outbreak Pathology medicine.medical_specialty Coronavirus disease 2019 (COVID-19) business.industry Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Autopsy Pathological anatomy medicine.disease Coagulation system Coagulopathy Medicine business Diffuse alveolar damage |
| Zdroj: | PULMONOLOGIYA. 30:519-532 |
| ISSN: | 2541-9617 0869-0189 |
| Popis: | The research aim is to study the morphological features of COVID-19 in the lungs of patients who died in Moscow from March 20 to June 6, 2020. Methods . Autopsy material of the lungs from 123 deceased (54 women, 69 men) with COVID-19 coronavirus infection (confirmed by PCR) was analyzed, the median age was 71 (30 – 94) years, and the duration of the disease was 14 (3 – 65) days. In all cases, the patient’s medical records and autopsy reports were analyzed. Macro- and microscopic changes in the lungs were evaluated in all the observations. Results . The pathology of the lungs in COVID-19 corresponds to various phases of diffuse alveolar damage (DAD). The exudative phase of DAD was detected in 54 (43.9%), the proliferative phase – in 21 (14.63%), and their combination – in 51 (41.46%) of the deceased. Histological features of different phases of DAD are described. Conclusion . An analysis of autopsy material revealed a mismatch between the duration of the course of the disease and the phase of diffuse alveolar damage. A significant portion of the dead found a combination of exudative and proliferative phases of the disease. Histological signs that indirectly indicate a violation of the coagulation system during COVID-19 are described. |
| Databáze: | OpenAIRE |
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