| Autor: |
Hugh J. Harrington, H. Richard Tyler, Thomas Flood, Mark Hallett, Norma Slater |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
Advances in Experimental Medicine and Biology ISBN: 9781468412024 |
| DOI: |
10.1007/978-1-4684-1200-0_48 |
| Popis: |
In a number of experimental situations exogenously administered gangliosides have been demonstrated to speed recovery from axonotmesis. First demonstrated for the pre-and postganglionic sympathetic fibers of the cat nictitating membrane,1 it has now been demonstrated also for the rat sciatic nerve2 and rat tail nerve.3 The mechanism of action seems to be stimulation of the sprouting process.3,4 Hence, gangliosides would be expected to be beneficial in conditions such as traumatic nerve injury and mononeuritis from focal nerve infarction. Therapy would reduce the time of disability. Additionally, if regrowth of nerve is sometimes limited by fibrosis in the region of injury, then rapid growth out of this region would improve the quality of recovery. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
