Cytomegalovirus urinary excretion and long term outcome in children with congenital cytomegalovirus infection
| Autor: | Antolin M. Llorente, Thomas Littman, W. Daniel Williamson, Gail J. Demmler, Daniel E. Noyola, Carol Griesser, Susan P. Williams, Martha D. Yow, Latasha Jarrett, Sherry L Sellers |
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| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
Human cytomegalovirus Pediatrics medicine.medical_specialty biology business.industry Congenital cytomegalovirus infection virus diseases biology.organism_classification medicine.disease Asymptomatic Excretion Infectious Diseases Betaherpesvirinae Pediatrics Perinatology and Child Health Immunology Medicine Sensorineural hearing loss Viral disease medicine.symptom Complication business |
| Zdroj: | The Pediatric Infectious Disease Journal. 19:505-510 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/00006454-200006000-00003 |
| Popis: | Background. Cytomegalovirus (CMV) is the most frequent cause of congenital infection, and both symptomatic and asymptomatic infants may have long term sequelae. Children with congenital CMV infection are chronically infected and excrete CMV in the urine for prolonged periods. However, the effect of prolonged viral replication on the long term outcome of these children is unknown. Objective. To determine whether duration of CMV excretion is associated with outcome at 6 years of life in symptomatic and asymptomatic congenitally infected children. Methods. Longitudinal cohort study. Children congenitally infected with CMV were identified at birth and followed prospectively in a study of long term effects of congenital CMV infection. The relationship between duration of CMV urinary excretion and growth, neurodevelopment and presence and progression of sensorineural hearing loss (SNHL) at 6 years of age was determined. Results. There was no significant difference in the duration of viral urinary excretion between children born with asymptomatic (median, 4.55 years) and symptomatic (median, 2.97 years) congenital CMV infection (P= 0.11). Furthermore there was no association between long term growth or cognitive outcome and duration of viral excretion. However, a significantly greater proportion of children who excreted CMV for 4 years (P= 0.019,P= 0.009, respectively). Conclusions. Children congenitally infected with CMV are chronically infected for years, but the duration of CMV urinary excretion is not associated with abnormalities of growth, or neurodevelopmental deficits. However, SNHL and progressive SNHL were associated with a shorter duration of CMV excretion. |
| Databáze: | OpenAIRE |
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