Synthesis of a bicyclic BPTI mimetic containing 4-thioproline replacing Cys38

Autor:	Christeen Halloun, Ron Kasher, Chaim Gilon, Gal Bitan
Rok vydání:	1998
Předmět:	Bicyclic molecule Biochemistry Chemistry Peptidomimetic Pharmacology toxicology medicine Binding site Trypsin Molecular medicine Bovine Pancreatic Trypsin Inhibitor medicine.drug
Zdroj:	Letters in Peptide Science. 5:101-103
ISSN:	1573-496X 0929-5666
DOI:	10.1007/bf02443447
Popis:	The synthesis of a backbone bicyclic nonapeptide that mimics the binding site of bovine pancreatic trypsin inhibitor (BPTI) is described. The BPTI mimetic, which contains cis-thioproline replacing Cys38 of the protein, inhibits trypsin with a Ki of 76 μM.
Databáze:	OpenAIRE
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