| Popis: |
As the global population ages, the incidence of stroke is predicted to increase. A stroke results in the loss of blood flow to the brain leading to cell death. The loss of neurons and glial cells results in functional impairments. Ischemic stroke is the most prevalent type of stroke and a result of thrombi formation. Nutrition is a modifiable risk factor for stroke. One-carbon metabolism, which includes folic acid, a B vitamin, and choline, a nutrient, is implicated in stroke risk. Reduced levels of folic acid or choline increase homocysteine levels. High levels of homocysteine are associated with the risk of cardiovascular disease, such as stroke. Folic acid and choline can act as methyl donors to reduce levels of homocysteine in the cell. The aim of this chapter is to discuss how homocysteine, folates, and choline are implicated in the onset of ischemic stroke. |
