Endoscopic fluorescence of gastrointestinal neoplasia after sensitization with 5-aminolaevulinic acid (ALA) or Photofrin
| Autor: | Sune Svanberg, Sune Montan, Annika Nilsson, Stephen G. Bown, Katarina Svanberg, Ingrid Wang-Nordman, Peter Mlkvy, Alexander J. MacRobert, Helmut Messmann |
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| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.diagnostic_test business.industry Colorectal cancer medicine.medical_treatment Cancer Photodynamic therapy medicine.disease Ulcerative colitis Gastroenterology Colon polyps Endoscopy medicine.anatomical_structure Internal medicine Biopsy medicine business Sensitization |
| Zdroj: | SPIE Proceedings. |
| ISSN: | 0277-786X |
| DOI: | 10.1117/12.203402 |
| Popis: | Fluorescence after photosensitization has the potential to identify lesions not visible on conventional endoscopy. We assessed 12 patients at high risk of or with established GI cancers (u ulcerative colitis, 1 colon polyp, 2 familial polyposis with duodenal polyps, 2 early oesophageal cancers). Fluorescence images (excitation 390 nm) were recorded with endoscopic equipment and additional spot measurements (optical multichannel analyzer). Patients were given 10 - 60 mg/kg ALA orally or 2 mg/kg Photofrin i.v. 60 mg/kg ALA gave high levels of PP IX (proto-porphyrin IX) in all areas, but 10 - 15 mg/kg resulted in selectivity in macroscopically inflamed colon. Photofrin gave oesophageal tumors selectivity at 4 and 48 hours. Photofrin patients subsequently had PDT. Photobleaching was documented in 3. We conclude that these techniques have potential as `optical biopsy tools' and for screening for early neoplastic changes.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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